CEBPA (CCAAT/enhancer-binding protein alpha) is a transcription factor that plays a significant role in regulating gene expression related to cell differentiation, proliferation, and metabolism. It is particularly important in the context of hematopoiesis (the formation of blood cells) and has been implicated in various cancers, especially acute myeloid leukemia (AML).
In general, altered expression of CEBPA, particularly downregulation, is often associated with more aggressive tumor behavior and poorer prognosis in various cancer types.
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