IL-22 has also been identified as a cancer-promoting cytokine since deregulation of the IL-22-IL-22R1 system is linked to different cancer entities including lung, breast, gastric, pancreatic and colon cancers.
IL-22 is often expressed in various cancers, including colorectal cancer, breast cancer, liver cancer, and lung cancer. Its expression can vary depending on the tumor type and the immune context.
Elevated levels of IL-22 are frequently associated with the presence of tumor-infiltrating immune cells and can be produced by both immune and tumor cells.
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