Interleukin-28 (IL-28), also known as IL-28A or IL-28B, is a member of the type III interferon family, which also includes IL-29. These cytokines play a role in the immune response, particularly in antiviral defense and the regulation of immune cell activity. IL-28 is produced by various cell types, including macrophages, dendritic cells, and epithelial cells, in response to viral infections and other stimuli.
A cytokine that comes in two isoforms, IL-28A and IL-28B, and plays a role in immune defense against viruses
IL-28 expression has been observed in various cancers, including hepatocellular carcinoma, colorectal cancer, and breast cancer. However, research on IL-28 in cancer is still relatively limited compared to other cytokines.
The expression of IL-28 can vary depending on the tumor type and the immune context, and it may be influenced by the presence of viral infections or inflammatory signals.
The prognostic significance of IL-28 in cancer is not yet fully established and may vary depending on the tumor type and the immune context.
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