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tid Target Cancers General Effect on Target
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Family is a major component of the basement membrane (BM) that has recently been found to be involved in tumor angiogenesis and progression.
Type IV collagen, an important component of the basement membrane, is highly expressed by pancreatic cancer cells both in vivo and in vitro. The interaction between type IV collagen produced by the cancer cell, and integrins on the surface of the cancer cells, are important for continuous cancer cell growth, maintenance of a migratory phenotype, and for avoiding apoptosis.




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