A crucial cell adhesion receptor involved in diverse biological processes.
ITGA11 expression is associated with poor prognoses. It significantly influences the tumor microenvironment by regulating collagen assembly and matrix remodeling, particularly through pathways such as TGF-β and Hedgehog signaling. Moreover, ITGA11 contributes to cancer progression via interconnected pathways like PI3K/AKT and PDGFBR/JNK, influencing tumor growth, invasion, and metastasis.
ITGA11 is also highly expressed in fibroblasts of head and neck, breast, pancreas, lung, colorectal and Gastric Cancer.
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