UCP1 for example has been shown to be expressed in prostate cancer and be related to a metastatic phenotype.
UCP1 and UCP3 are overexpressed in a large subgroup of non-small cell lung tumors and their expression coincides with increased glucose absorption, intensified glycolysis, and anaerobic glucose usage.
UCP1 was negatively regulated to the process of TNBC. Overexpression of UCP1 could impair the malignant behavior of triple-negative breast cancer. UCP1 was down-regulated in colorectal cancer while positively related to a better prognosis.
UCP1 is a mitochondrial inner membrane protein most notably expressed in brown adipose tissue, where it uncouples oxidative phosphorylation to produce heat rather than ATP.
– In cancer cachexia, increased UCP1 expression is linked to higher energy dissipation, contributing to weight loss and weakness, which can indirectly influence patient prognosis.
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