Coiled-coil domain-containing (CCDC) proteins constitute a class of homo-oligomeric or oligomeric sequence proteins containing two or more coiled-coil structural domains, crucial for the assembly and arrangement of the cytoskeleton.
CCDC150 is a prognostic marker in Kidney renal clear cell carcinoma, Pancreatic adenocarcinoma Cancer.
CCDC150, which exhibited abnormal expression in TNBC and responded to gradient RMF.
CCDCs participate in the formation of backbone proteins and the polymerization of actin, which is pivotal in driving the epithelial–mesenchymal transition of tumor cells. Abnormal up-regulation of some CCDCs is found in tumors, and they are positively correlated with tumor metastasis. For instance, CCDC6 exhibits aberrantly high expression in thyroid cancer, and CCDC66 is significantly up-regulated in colorectal cancer to promote tumor invasion and metastasis. We found that the expression of CCDC150 in TNBC was significantly increased.
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