A gene that encodes a cytosolic adapter protein necessary for both innate and adaptive immune response.
The expression of MyD88 is elevated in tumor tissues compared to normal tissues, such as those found in breast, lung, liver, colon, and stomach organs.
Researchers have drawn contradictory conclusions regarding the role of MyD88 therein. The reason may be, on one hand, inhibiting MyD88 may weaken immune function, resulting in compromised immune surveillance against tumor cells and a reduced ability to eliminate pathogenic factors. This scenario can promote the emergence and progression of tumors. On the other hand, suppressing MyD88 might alleviate inflammation, thus preventing inflammation-associated tumorigenesis.
MYD88 (myeloid differentiation primary response 88) is a key adaptor protein involved in the signaling pathways of the immune system, particularly in the Toll-like receptor (TLR) and interleukin-1 receptor (IL-1R) pathways.
Elevated MYD88 expression or the presence of MYD88 mutations can be associated with poor prognosis in certain cancers.
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