NFAT is a family of transcription factors that play a crucial role in the regulation of gene expression in various cell types, including immune cells and cancer cells. NFAT proteins are involved in the regulation of cell growth, differentiation, and survival, and their dysregulation has been implicated in the development and progression of cancer.
NFAT family: NFAT1, NFAT2, NFAT3, NFAT4, and NFAT5.
Cell proliferation: NFAT proteins can regulate the expression of genes involved in cell cycle progression and cell growth, which can contribute to the development of cancer.
• Angiogenesis: NFAT proteins have been implicated in the regulation of angiogenesis, the process of new blood vessel formation, which is essential for tumor growth and metastasis.
• Metastasis: NFAT proteins can regulate the expression of genes involved in cell migration and invasion, which can contribute to the development of metastatic disease.
• Immune evasion: NFAT proteins can regulate the expression of genes involved in immune evasion, which can allow cancer cells to evade the immune system.
Studies have shown that NFAT proteins are overexpressed in several types of cancer, including breast, lung, and colon cancer.
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