REL, is a protein that plays a crucial role in the regulation of cell growth, differentiation, and survival. REL is a member of the NF-κB family of transcription factors, which are involved in various cellular processes, including immune responses, inflammation, and cell proliferation.
REL has been implicated in the development and progression of various types of cancer, including lymphomas, leukemias, and solid tumors. The protein is often constitutively active in cancer cells, leading to the activation of genes involved in cell proliferation, survival, and angiogenesis.
Studies have shown that REL is overexpressed in several types of cancer.
REL can also interact with other transcription factors, such as p50 and p65, to form heterodimers that regulate gene expression.
-Activation of cell cycle progression: REL can activate genes involved in cell cycle progression, leading to increased cell proliferation.
-Inhibition of apoptosis: REL can inhibit apoptosis by activating anti-apoptotic genes and repressing pro-apoptotic genes.
-Promotion of angiogenesis: REL can activate genes involved in angiogenesis, leading to increased blood vessel formation and tumor growth.
-Modulation of immune responses: REL can modulate immune responses by regulating the expression of genes involved in inflammation and immune cell activation.
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