Furin is a type of protease enzyme that plays a crucial role in the processing and activation of various proteins involved in cell growth, differentiation, and survival.
Furin is overexpressed in many types of cancer, including breast, lung, colon, and prostate cancer. This overexpression can lead to the activation of various oncogenic proteins, such as growth factors, receptors, and adhesion molecules, which can promote tumor growth, invasion, and metastasis.
Furin can activate growth factors such as TGF-β, PDGF, and VEGF, which can promote tumor growth and angiogenesis.
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