A family of enzymes that play a crucial role in the folding and assembly of disulfide bond-containing proteins.
PDI proteins are typically found in the endoplasmic reticulum (ER), but in cancer cells, they can be expressed on the cell surface, where they can interact with other proteins and influence cell behavior.
PDI proteins can promote tumor cell survival by regulating the folding and stability of proteins involved in apoptosis (programmed cell death) and cell stress responses.
PDI proteins can contribute to angiogenesis (the formation of new blood vessels) by regulating the activity of vascular endothelial growth factor (VEGF), a key pro-angiogenic factor.
PDI-A1: Overexpressed in various types of cancer, including breast, lung, and colon cancer, and associated with poor prognosis.
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