ABC (ATP-binding cassette) transporters are a family of proteins that play a crucial role in the transport of various molecules across cell membranes.
ABC transporters have been implicated in the development of multidrug resistance, which is a major obstacle in cancer treatment.
Overexpression of certain ABC transporters, such as P-glycoprotein (P-gp), has been observed in various types of cancer, including breast, lung, and colon cancer.
Examples of ABC transporters implicated in cancer include:
- P-glycoprotein (P-gp, ABCB1)
- Multidrug resistance-associated protein 1 (MRP1, ABCC1)
- Breast cancer resistance protein (BCRP, ABCG2)
Prognostic Implications
-Drug Resistance: High expression of ABC transporters is often linked to resistance against chemotherapy, leading to treatment failure and poor patient outcomes.
-Survival Rates: Patients with tumors expressing high levels of certain ABC transporters may have lower overall survival rates.
Target for Therapy: Inhibitors of ABC transporters are being explored as potential adjuncts to improve the efficacy of chemotherapy.
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