PTP1B (protein tyrosine phosphatase 1B) is a protein that has been linked to the development and progression of certain types of cancer. It plays a role in regulating insulin signaling, and dysregulation of this pathway can contribute to cancer cell growth and survival.
In cancer cells, PTP1B has been shown to promote processes such as epithelial-mesenchymal transition (EMT), which allows cancer cells to become more invasive and metastatic.
PTP1B inhibitors have been shown to reduce tumor growth and metastasis in various cancer models.
In general, PTP1B expression is upregulated in cancer cells, which can contribute to cancer progression and resistance to therapy.
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