PSMB5 is a gene that provides instructions for making a protein called proteasome subunit beta type-5. This protein is a part of the larger proteasome complex, which helps break down unneeded or damaged proteins in the cell.
PSMB5 is a key component of the proteasome complex whose altered expression or mutation plays an important role in cancer biology. In hematologic malignancies—especially multiple myeloma—elevated levels or mutant forms of PSMB5 are associated with resistance to proteasome inhibitors and poorer outcomes. In solid tumors, increased proteasome activity via PSMB5 may support tumor cell survival under proteotoxic and metabolic stress, although its prognostic value can be more variable.
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