TRIF (Toll/IL-1 receptor domain-containing adaptor-inducing interferon-β) is a protein that plays a crucial role in the innate immune response, particularly in the activation of interferons and the production of pro-inflammatory cytokines.
Research has shown that TRIF is involved in the regulation of cancer development and progression. Here are some ways in which TRIF is linked to cancer:
• Tumor suppression: TRIF has been shown to have tumor-suppressive effects in certain types of cancer, such as breast, lung, and colon cancer. It does this by activating interferons and other anti-tumor immune responses.
Downregulated in: Breast, Lung, CRC
Upregulated in: Melanoma, GBM
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