PIAS-3 (Protein Inhibitor of Activated STAT-3) is a protein that plays a crucial role in regulating various cellular processes, including cell growth, differentiation, and survival. In the context of cancer, PIAS-3 has been found to have both tumor-suppressing and tumor-promoting effects, depending on the type of cancer and the specific cellular context.
In several cancers (e.g., glioblastoma, breast cancer, and lung cancers), reduced levels of PIAS3 have been reported.
– Downregulation of PIAS3 can result in unchecked STAT3 activity, which contributes to tumor progression and therapeutic resistance.
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