SSAT gene (Spermidine/Spermine N1-Acetyltransferase) is a gene that encodes an enzyme involved in the regulation of polyamine metabolism. Polyamines, such as spermidine and spermine, are small molecules that play a crucial role in various cellular processes, including cell growth, proliferation, and differentiation.
The SSAT enzyme is responsible for the acetylation of spermidine and spermine, which is a key step in the degradation of these polyamines. The SSAT gene is located on chromosome 2q31.1 and is expressed in various tissues, including the liver, kidney, and brain.
Dysregulation of the SSAT gene has been implicated in various diseases, including cancer. Overexpression of the SSAT gene has been observed in certain types of cancer, such as breast, prostate, and colon cancer.
Overexpression: Breast, Prostate, Colon
Underexpressed: Ovarian, lung
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