CREB-binding protein (CBP) is a multifunctional coactivator that plays a crucial role in the regulation of gene expression. It interacts with various transcription factors, including the cAMP response element-binding protein (CREB), and is involved in numerous cellular processes, such as cell growth, differentiation, and apoptosis.
CBP can act as a tumor suppressor. For example, it can mediate the transcriptional activation of genes that promote apoptosis or inhibit cell proliferation. Loss of CBP function can lead to decreased expression of these protective genes, contributing to cancer progression.
CBP interacts with several oncogenic signaling pathways, including:
Wnt/β-catenin Pathway: CBP is a coactivator for β-catenin, a key player in the Wnt signaling pathway, which is often dysregulated in cancers.
CBP is also involved in the Hedgehog signaling pathway, which is important for embryonic development and has been implicated in the growth of certain tumors.
The expression of CREB-binding protein (CBP) in cancer is complex, with both overexpression and loss of function observed in different cancer types.
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