14-3-3 proteins are a family of conserved regulatory molecules that play a crucial role in various cellular processes, including cell cycle regulation, apoptosis, and signal transduction.
14-3-3 proteins bind to a wide range of proteins, including kinases, phosphatases, and transcription factors, and modulate their activity, localization, and stability.
14-3-3 proteins can bind to and inhibit pro-apoptotic proteins, such as BAD and BAX, and promote cell cycle progression by binding to and activating cyclin-dependent kinases.
Overexpression: breast, lung, ovarian, pancreatic
Altered: colon, prostate, liver brain
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