ERCC1 (Excision Repair Cross Complementation group 1) is a protein that plays a crucial role in the repair of DNA damage caused by environmental factors, such as ultraviolet light and chemicals. It is involved in the nucleotide excision repair (NER) pathway, which is responsible for removing damaged DNA segments and repairing them.
In the context of cancer, ERCC1 has been found to be overexpressed in various types of tumors, including lung, colon, and ovarian cancers.
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