MRP is a family of ATP-binding cassette (ABC) transporters that are involved in the efflux of various compounds, including chemotherapeutic agents, from cells. There are several members of the MRP family, including MRP1 (ABCC1), MRP2 (ABCC2), MRP3 (ABCC3), and others.
MRP proteins are overexpressed in various types of cancer, including breast, lung, colon, and leukemia. This overexpression can lead to the efflux of chemotherapeutic agents from cancer cells, making them resistant to treatment.
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