CTNNB1, which encodes the protein beta-catenin, plays a significant role in the Wnt signaling pathway, which is crucial for cell proliferation, differentiation, and adhesion. Mutations in the CTNNB1 gene can lead to the stabilization and accumulation of beta-catenin in the cytoplasm and nucleus, resulting in the activation of Wnt target genes that promote oncogenesis.
CTNNB1 mutations are commonly associated with several types of cancer.
CTNNB1 (which encodes beta-catenin) is considered an oncogene when it is mutated or dysregulated.
Overall, CTNNB1 expression and its mutations are often associated with poor prognosis across various cancer types.
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