miR-497 has been identified as a tumor suppressor miRNA, and its downregulation has been observed in various types of cancer, including breast, lung, colon, and ovarian cancer. The expression of miR-497 is often reduced in cancer cells, which can lead to the upregulation of target genes involved in cell proliferation, apoptosis, and metastasis.
miR-497 targets several oncogenes, including: BCL2, cyclin D1, cyclin E1, IGF1R.
(Will delete Record if Target field = "Delete") Home