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tid Target Cancers General Effect on Target
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MicroRNAs (miRNAs) are small non-coding RNAs that play a crucial role in regulating gene expression by binding to the 3' untranslated region (3' UTR) of target mRNAs, leading to their degradation or inhibition of translation.
miR-130a is overexpressed in several types of cancer: breast, lung, CRC, ovarian.
key targets of miR-130a: Tp53, PTEN, SMAD4, RUNX3.

miR-130a is generally considered protumorigenic in many contexts. Its ability to target and downregulate tumor suppressor genes can facilitate tumor growth, invasion, and metastasis.




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