PD-L2 is a protein that plays a crucial role in the regulation of the immune system, particularly in the context of cancer. It is a ligand for the PD-1 (Programmed Death-1) receptor, which is expressed on the surface of T cells.
PD-L2 is often overexpressed on the surface of tumor cells, where it can interact with PD-1 on T cells. This interaction can lead to the inhibition of T cell activation and proliferation, allowing the tumor cells to evade immune surveillance and continue to grow and proliferate.
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