FoxP3+ refers to cells that express the FoxP3 protein.
Immune Suppression: FOXP3+ Tregs are known for their ability to suppress immune responses. In the context of cancer, they can inhibit the activity of effector T cells and other immune cells, allowing tumors to evade immune detection.
Tumor Microenvironment: The presence of FOXP3+ Tregs in the tumor microenvironment is often associated with an immunosuppressive environment, which can facilitate tumor growth and metastasis.
FOXP3+ Tregs in Specific Cancers
Breast Cancer:
Expression: FOXP3+ Tregs are present in the tumor microenvironment.
Prognosis: High levels of FOXP3+ Tregs are often linked to better prognosis, indicating a potential anti-tumor immune response.
Lung Cancer:
Expression: FOXP3+ Tregs are found in the tumor microenvironment.
Prognosis: Increased FOXP3+ Tregs can correlate with poor prognosis, suggesting immune evasion.
So expression is high, but prognosis can vary.
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