CYLD (Cylindromatosis) is a gene that encodes a deubiquitinating enzyme, which plays a crucial role in various cellular processes, including the regulation of cell signaling pathways. Mutations in the CYLD gene are associated with several types of cancer, particularly those related to skin and other epithelial tissues.
Research has also indicated that CYLD may play a role in other cancers, including breast cancer and colorectal cancer. The exact mechanisms by which CYLD mutations contribute to these cancers are still being studied, but they may involve dysregulation of signaling pathways such as NF-κB and Wnt.
CYLD is primarily known as a tumor suppressor gene. Its protein product functions to remove ubiquitin from target proteins, thereby regulating various signaling pathways, including those involved in cell proliferation, apoptosis, and inflammation. Loss of CYLD function can lead to uncontrolled cell growth and tumorigenesis.
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