SMG1 (Suppressor of Morphogenetic Defects in Genitalia 1) is a gene that plays a crucial role in the regulation of DNA damage response and cell cycle progression.
SMG1 is a phosphatidylinositol 3-kinase-related kinase (PIKK) that is activated in response to DNA damage. It phosphorylates and activates downstream targets, including p53, a tumor suppressor protein that plays a key role in preventing cancer. SMG1 also regulates the cell cycle by phosphorylating and inhibiting the activity of cyclin-dependent kinases (CDKs), which are essential for cell cycle progression.
Studies have shown that SMG1 is frequently downregulated or mutated in various types of cancer, including breast, lung, and colon cancer.
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