β-TRCP (beta-transducin repeat-containing protein) is a protein that plays a crucial role in the regulation of various cellular processes, including cell cycle progression, apoptosis, and DNA damage response. It is a component of the SCF (Skp1-Cullin-F-box) complex, a type of E3 ubiquitin ligase that targets specific proteins for degradation by the proteasome.
Overexpression of β-TRCP has been associated with poor prognosis and increased tumor aggressiveness.
Elevated expression in: breast, lung, colon, prostate, ovarian, pancreatic, GBM HCC, Esophageal, Stomach.
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