VGCCs play a crucial role in various cellular processes, including cell signaling, proliferation, and differentiation.
VGCCs are transmembrane proteins that regulate the influx of calcium ions into cells. Calcium ions act as a second messenger, triggering various signaling pathways that control cell growth, survival, and migration. In cancer cells, VGCCs can be overexpressed or mutated, leading to aberrant calcium signaling and contributing to tumor growth and metastasis.
Overexpressed in: breast cancer, prostate cancer, colorectal cancer, glioblastoma
Associated with: tumor growth, metastasis, and poor prognosis.
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