PFKP (Phosphofructokinase, Platelet) is an enzyme that plays a crucial role in glycolysis, the process by which cells convert glucose into energy. PFKP is a key regulatory enzyme in the glycolytic pathway, and it is primarily expressed in platelets and other hematopoietic cells.
PFKP has been shown to be overexpressed in certain types of tumors, including leukemia and lymphoma. This overexpression may contribute to the development and progression of cancer by promoting glycolysis and energy production in cancer cells.
PFKP is a key regulatory enzyme in the glycolytic pathway.
PFKP plays a role in the regulation of glucose metabolism in diabetes.
PFKP is involved in the regulation of platelet function and thrombosis.
– PFKP is one of the isoforms of phosphofructokinase-1 (PFK-1), a key regulatory enzyme in glycolysis that catalyzes the conversion of fructose-6-phosphate to fructose-1,6-bisphosphate.
– As a rate-limiting enzyme in glycolysis, PFKP plays a crucial role in controlling the metabolic flux through this pathway, especially in proliferating cells that require higher energy and biosynthetic intermediates.
– Upregulated Expression: Many tumors demonstrate an increased expression of PFKP, which is consistent with the observed reliance on glycolysis (even in the presence of oxygen) for rapid energy production and biosynthesis.
– Metabolic Reprogramming: The overexpression of PFKP contributes to the enhanced glycolytic rate in cancer cells, supporting tumor growth, survival, and aggressiveness.
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