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tid Target Cancers General Effect on Target
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miR-34b-5p is downregulated in several types of cancer: CRC, breast, lung, prostate. The tumor suppressor function of miR-34b-5p is thought to be mediated by its ability to target and downregulate genes involved in cell proliferation, survival, and metastasis. Some of the target genes of miR-34b-5p include:

• BCL-2: an anti-apoptotic protein that promotes cell survival.
• CCND1: a cyclin-dependent kinase that promotes cell cycle progression.
• VEGF: a vascular endothelial growth factor that promotes angiogenesis (the formation of new blood vessels).




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