Cytochrome P450 (CYP) enzymes are a large family of enzymes that play a crucial role in the metabolism of various substances, including drugs, environmental chemicals, and endogenous compounds. They are primarily found in the liver but are also present in other tissues.
Tumor Microenvironment: CYP enzymes can also be expressed in tumor tissues, where they may contribute to the local metabolism of drugs and other compounds, potentially affecting tumor growth and response to therapy.
Some CYPs may be upregulated, while others may be downregulated.
CYP1B1 is often overexpressed in breast, prostate, and lung cancers. This overexpression can contribute to the activation of procarcinogens and the metabolism of therapeutic agents, potentially influencing tumor growth and response to treatment.
CYP19A1 (aromatase) converts androgens to estrogens, and its expression can be associated with breast cancer progression.
Specific CYP enzymes, such as CYP1A1, CYP1B1, CYP17A1, and CYP19A1, have been associated with tumor progression and poor outcomes in various cancers.
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