STAC2 (SH3 and cysteine-rich domain 2) is a a novel voltage-gated calcium channel protein.
Overexpressed in: breast, prostate, lung, ost, CRC cancers.
STAC2 also interacts with other signaling pathways to promote cancer progression. For example, STAC2 interacts with the PI3K/AKT signaling pathway to promote cell survival and the NF-κB signaling pathway to promote inflammation and cell proliferation.
target genes of STAC2 include: VEGF, MMPs, BCL-2, Cyclin D1
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