Death-domain associated proteins are a group of proteins that play crucial roles in the regulation of apoptosis (programmed cell death) and other cellular processes.
-Apoptosis Regulation: Proteins with death domains, such as Fas (CD95) and its ligand (FasL), play essential roles in the extrinsic pathway of apoptosis. Dysregulation of these pathways can lead to cancer cell survival.
Generally, lower levels of DAXX or mutations in the DAXX gene are associated with poorer outcomes and increased tumor aggressiveness.
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