RHBDD1 encodes a member of the rhomboid family of intramembrane serine proteases. Although the precise functions of RHBDD1 are still being elucidated, emerging evidence suggests that it may influence several cancer-related processes including cell proliferation, apoptosis, and migration. Its enzymatic role within the cell, particularly in the modulation of signaling pathways through regulated proteolysis, is thought to contribute to changes in the tumor microenvironment and tumor progression.
In certain cancer types—such as colorectal, hepatocellular, or breast cancers—RHBDD1 expression has been found to be upregulated.
The increased expression of RHBDD1 in tumors suggests that it may contribute to oncogenic transformation or progression.
Higher levels of RHBDD1 expression have been associated with increased tumor proliferation and poorer survival rates in some cancers.
RHBDD1 holds promise both as a prognostic biomarker and as a potential therapeutic target.
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