Trx is a small protein that acts as a reducing agent, donating electrons to reduce oxidized proteins and other molecules.
Trx is overexpressed in various types of cancer, including breast, lung, colon, and prostate cancer.
- Cytosolic thioredoxin (TRX-1) and mitochondrial thioredoxin (TRX-2).
- Thioredoxin is a pivotal redox regulator that protects cells from oxidative stress and supports survival and proliferation.
- There is interest in combining thioredoxin inhibitors with conventional chemotherapy or radiotherapy to sensitize tumors to oxidative stress and improve treatment efficacy.
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