IGFR (Insulin-like Growth Factor Receptor) is a protein that plays a crucial role in cell growth and division. It is a receptor tyrosine kinase that is activated by its ligands, IGF-1 (Insulin-like Growth Factor 1) and IGF-2.
IGFR is typically overexpressed and associated with poorer prognosis.
IGF-1R is often overexpressed in several types of cancers, including breast cancer, prostate cancer, colorectal cancer, lung cancer, and sarcomas. Its expression can vary significantly depending on the tumor type and stage.
High levels of IGF-1R expression are frequently associated with aggressive tumor behavior and poor prognosis.
IGF-1R is considered an oncogene due to its role in promoting cell proliferation, survival, and metastasis. Activation of IGF-1R leads to the activation of several downstream signaling pathways, including the PI3K/Akt and MAPK pathways, which are critical for cell growth and survival.
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