Polycomb repressive complex 2 (PRC2) is a key epigenetic regulator that plays a crucial role in maintaining cellular identity and suppressing tumor formation.
PRC2 is a histone methyltransferase complex that catalyzes the trimethylation of histone H3 lysine 27 (H3K27me3), a repressive epigenetic mark that silences gene expression. PRC2 is composed of four core subunits: EZH2 (enhancer of zeste homolog 2), SUZ12, EED, and RbAp46/48.
PRC2 is often overexpressed or mutated, leading to aberrant epigenetic regulation and contributing to tumorigenesis.
EZH2, the catalytic subunit of PRC2, is often overexpressed in various types of cancer.
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