Serine proteases are a family of enzymes that play a crucial role in various cellular processes, including cell growth, differentiation, and survival.
Role of serine proteases in cancer:
-Tumor growth and angiogenesis: Serine proteases, such as urokinase-type plasminogen activator (uPA) and plasminogen activator inhibitor-1 (PAI-1), are involved in the regulation of tumor growth and angiogenesis.
-Invasion and metastasis: Serine proteases, such as (MMPs) and cathepsins, are involved in the degradation of the extracellular matrix, facilitating tumor cell invasion and metastasis.
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