NAD-dehydrogenases, also known as NADH dehydrogenases or NADH:quinone oxidoreductases, are a group of enzymes that play a crucial role in the electron transport chain (ETC) of mitochondria. These enzymes are responsible for catalyzing the transfer of electrons from NADH to the electron transport chain, ultimately contributing to the generation of ATP (adenosine triphosphate) during cellular respiration.
Complex I (NADH dehydrogenase): This is the largest and most complex enzyme in the electron transport chain, consisting of 45 subunits. It is responsible for transferring electrons from NADH to the electron transport chain.
NADH stands for Nicotinamide Adenine Dinucleotide (in its reduced form). It is a vital coenzyme found in all living cells, primarily involved in redox (oxidation–reduction) reactions. In its reduced form (NADH), it carries electrons that are used in various metabolic pathways, including ATP production in the mitochondrial electron transport chain.
NAD-dehydrogenases play a crucial role in the generation of ATP during cellular respiration.
NAD-dehydrogenases help regulate the redox state of the cell by controlling the levels of NADH and NAD+.
NAD-dehydrogenases can also function as antioxidants, helping to protect the cell from oxidative damage.
NADH is the substrate (electron donor), NADH dehydrogenases are the enzymes that help process NADH by removing its electrons.
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