Transferrin is a glycoprotein found in the blood that binds and transports iron throughout the body.
Its primary role is to deliver iron to various tissues, especially to cells that require iron for processes like hemoglobin synthesis.
Transferrin itself is a circulating protein primarily produced by the liver.
Although its serum levels are clinically monitored (e.g., in iron studies and nutritional assessments), cancer-related studies more commonly focus on uptake mechanisms (via the transferrin receptor) rather than on changes in transferrin production per se.
In some tumor microenvironments, local factors might influence transferrin levels, but the clinical focus tends to be on how cancer cells take up iron.
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