(Carnitine Acyltransferase) is an enzyme that plays a crucial role in the metabolism of fatty acids. In the context of cancer, CAT expression has been studied in various types of tumors.
(Carnitine Acyltransferase) is typically upregulated in various types of cancer. Studies have shown that CAT expression is increased in many types of cancer, including breast, colorectal, prostate, lung, liver, pancreatic, and glioblastoma, among others.
High expression is linked to poor prognosis.
Carnitine acyltransferases” is an umbrella term covering a family of enzymes involved in the transport and metabolism of acyl‐groups (typically long‐chain fatty acids) by conjugation with carnitine. The key members include:
CPT1 (Carnitine Palmitoyltransferase 1) -frequently upregulated in cancer
CPT2 (Carnitine Palmitoyltransferase 2)
CACT (Carnitine Acylcarnitine Translocase)
CrAT (Carnitine Acetyltransferase
Many studies have shown that enzymes facilitating fatty acid oxidation (especially CPT1A) can be upregulated in cancers that rely on fatty acid oxidation to boost their energy production and support biosynthesis. This upregulation is an adaptation to increased energy demands and altered nutrient availability.
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