TCF4 gene (Transcription Factor 4) is a transcription factor that plays a crucial role in the Wnt/β-catenin signaling pathway, which is involved in cell proliferation, differentiation, and survival.
TCF4 gene has been found to be:
Amplified in 15% of breast cancer cases
Mutated in 10% of lung cancer cases
Deleted in 20% of prostate cancer cases
Methylated in 30% of colorectal cancer cases
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