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tid Target Cancers General Effect on Target
Name
Source
Type

Also known as PTGER2
EP2 (Prostaglandin E2 receptor 2) is a receptor that plays a role in various cellular processes, including inflammation and cell growth. In cancer, EP2 has been implicated in tumor development and progression.
Tumorigenic potential:
-promote tumorigenesis by enhancing cell proliferation and survival
-Increasing angiogenesis (formation of new blood vessels)
-Suppressing apoptosis (programmed cell death)
-Promoting invasion and metastasis

Expression levels in cancer:
Overexpressed in:Colorectal, Breast, Lung, Prostate, and Ovarian cancer (with generally poor prognosis)
Underexpressed in:Some types of gastric cancer (correlated with improved overall survival)




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