Endoglin, also known as CD105, is a glycoprotein that is primarily expressed on the surface of endothelial cells and is involved in angiogenesis, the process of new blood vessel formation.
Elevated levels of endoglin have been associated with poor prognosis in various cancers, including breast, colorectal, and lung cancers. Its expression levels may serve as a biomarker for tumor progression and response to therapy.
Many solid tumors such as breast, lung, colon, and pancreatic cancers exhibit high CD105 expression in their peritumoral and intratumoral vasculature. This is often used as a surrogate marker for the extent of angiogenesis.
CD105 (endoglin) is a pivotal protein in the regulation of angiogenesis. In cancer, its high expression—especially on the endothelial cells of tumor vasculature—is often associated with increased angiogenic activity, aggressive tumor behavior, and poorer prognosis.
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