MUC1-C is a truncated form of the MUC1 protein that is generated through alternative splicing.
MUC1-C lacks the extracellular domain of MUC1 and is instead localized to the cytoplasm and nucleus.
MUC1-C has been shown to have distinct functions from MUC1, including the regulation of cell growth, survival, and transformation.
MUC1-C is often overexpressed in cancer cells and can contribute to oncogenesis by promoting cell proliferation, inhibiting apoptosis, and enhancing metastasis.
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