H3K27ac is a histone modification that is associated with active gene expression. Here are some key points about H3K27ac and its relationship to cancer:
Elevated in: breast, lung, colon, prostate ,Cancer stem cells and progenitor cells.
High levels of H3K27ac are associated with poor prognosis in:Breast,Lung,CRC cancer.
Low levels of H3K27ac are associated with good prognosis in:
Certain types of leukemia and lymphoma (correlated with increased overall survival and disease-free survival).
H3K27ac has been shown to play a role in the regulation of various oncogenes, including:
MYC
Cyclin D1
CDK4
Inhibition of H3K27ac has been shown to suppress tumor growth and induce apoptosis in various types of cancer.
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