Bfl-1 (also known as A1 in some contexts) in the context of cancer biology, its role in apoptosis regulation, and its relevance to immunotherapy.
• Bfl-1 is a member of the BCL2 protein family, which comprises both pro- and anti-apoptotic regulators.
• Also known as A1 in several species, Bfl-1 is an anti-apoptotic protein that contributes to cell survival by binding and sequestering pro-apoptotic factors.
• This interaction helps prevent the initiation of the mitochondrial (intrinsic) pathway of apoptosis.
– Several studies have found that Bfl-1 can be overexpressed in various malignancies.
– Its increased expression allows cancer cells to resist apoptosis induced by both intrinsic cellular stress and extrinsic signals, contributing to tumor development and progression.
(Will delete Record if Target field = "Delete") Home